About the StudyPortuguês
This international multisite study investigates how the brains of people with obsessive-compulsive disorder (OCD) work in comparison to the brains of healthy individuals.
There is a need for a large well-powered multimodal imaging study in well-characterized unmedicated OCD patients that transcend countries and cultures. In addition, the need to identify robust biosignatures of core OCD features across countries and cultures has also been expressed. These signatures may then be used to chart how the disease develops and to develop tailored treatments for populations across the globe.
The short-term goal of this study is to identify brain signatures associated with cognitive and clinical profiles common in individuals with OCD that are reproducible across countries and cultures of OCD, leveraging global collaboration both to recruit a very large unmedicated sample and to prove these signatures’ reproducibility.
The long-term goal is to identify brain signatures for measurable behaviors and clinical symptoms that cut across traditional diagnostic categories and to use these signatures to transform how we conceptualize, diagnose and ultimately treat mental illnesses like OCD. This multinational project allows the researchers to gather a wealth of data on the brain functioning and structure of people with OCD, rendering a significant contribution to existing knowledge about the brain of people with OCD from different cultures and nationalities.